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After the Aztec capital Tenochtitlan fell to the Spanish in 1521, Hernán Cortés despatched Pedro de Alvarado to Guatemala with 180 cavalry, 300 infantry, 4 cannons, and thousands of allied warriors from central Mexico.
Suleiman the Magnificent (1520–1566) captured Belgrade in 1521.
Saint Peter Canisius, Dutch Jesuit Catholic priest, was born in Nijmegen, Netherlands.
The first Mass in the Philippines is believed to have taken place on the Island of Limasawa, but may have also taken place on Masao in Butuan.
The Archipelago of St Lazarus, Philippines was taken possession of by Ferdinand Magellan.
During the era of Portuguese exploration known as "Manuel The Fortunate", the King of Portugal died at the age of 52.
Pope Sixtus V was born in Grottammare, Papal States.
The Duke of Soria, Willem van Croij, passed away at the age of 62.
Ferdinand Magellan's fleet made it to Cebu.