What happened 1545 AD

Sayri Túpac (c. 1535–1561) was an Inca ruler in Peru. He was the son of siblings Manco Inca Yupanqui and Cura Ocllo. After the death of his mother in 1539 and of his father in 1544, both at the hands of Spanish conquerors, he became the ruler of the Neo-Inca State in Vilcabamba. He ruled until 1560.

Mary Rose, King Henry VIII's flagship, died at the age of 73.

The Duke of Parma and an Italian diplomat, Alessandro Farnese, was born in Rome.