The CIA and the Democratic Revolutionary Front had based a 1,400-strong army, Brigade 2506, in Nicaragua. On the night of 16 to 17 April, Brigade 2506 landed along Cuba's Bay of Pigs and engaged in a firefight with a local revolutionary militia .
During the night of 16/17 April, a mock diversionary landing was organized by CIA operatives near Bahía Honda, Pinar del Río Province. A flotilla containing equipment that broadcast sounds and other effects of a shipborne invasion landing provided the source of Cuban reports that briefly lured Fidel Castro away from the Bay of Pigs battlefront area.
At about 00:00 on 17 April 1961, the two CIA LCIs Blagar and Barbara J, each with a CIA 'operations officer' and an Underwater Demolition Team (UDT) of five frogmen, entered the Bay of Pigs (Bahía de Cochinos) on the southern coast of Cuba. They headed a force of four transport ships (Houston, Río Escondido, Caribe and Atlántico) carrying about 1,400 Cuban exile ground troops of Brigade 2506, plus the Brigade's M41 Walker Bulldog tanks, and other vehicles in the landing craft.
On April 17, 1961, 1,400 U.S.-trained Cuban exiles invaded Cuba during the Bay of Pigs Invasion. Guevara did not play a key role in the fighting, as one day before the invasion a warship carrying Marines faked an invasion off the West Coast of Pinar del Río and drew forces commanded by Guevara to that region.
At about 01:00, Blagar, as the battlefield command ship, directed the principal landing at Playa Girón (code-named Blue Beach), led by the frogmen in rubber boats followed by troops from Caribe in small aluminium boats, then LCVPs and LCUs with the M41 Walker Bulldog tanks. Barbara J, leading Houston, similarly landed troops 35 km further northwest at Playa Larga (code-named Red Beach), using small fiberglass boats. The unloading of troops at night was delayed, due to engine failures and boats damaged by unforeseen coral reefs; the CIA had originally believed that the coral reef was seaweed. As the frogmen came in, they were shocked to discover that the Red Beach was lit with floodlights, which led to the location of the landing being hastily changed. As the frogmen landed, a firefight broke out when a jeep carrying Cuban militia happened by. The few militias in the area succeeded in warning Cuban armed forces via radio soon after the first landing, before the invaders overcame their token resistance.
Brigade 2506's M41 Walker Bulldog tanks had all landed by 7:30 am at Blue Beach and all of the troops by 8:30 am. Neither San Román at Blue Beach nor Erneido Oliva at Red Beach could communicate as all of the radios had been soaked in the water during the landings.
At about 11:00 am, the Cuban government began an offensive to take San Blas. San Román ordered all of the paratroopers back in order to hold San Blas, and they halted the offensive. During the afternoon, Castro kept the brigadistas under steady air attack and artillery fire, but did not order any new major attacks.
At 14:00, President Kennedy received a telegram from Nikita Khrushchev in Moscow, stating the Russians would not allow the US to enter Cuba, and implied swift nuclear retribution to the United States heartland if their warnings were not heeded.
During the night of 17–18 April, the force at Red Beach came under repeated counter-attacks from the Cuban Army and militia. As casualties mounted and ammunition was used up, the brigadistas steadily gave way. Airdrops from four C-54s and 2 C-46s had only limited success in landing more ammunition.
As the men from Red Beach arrived at Girón, San Román and Oliva met to discuss the situation. With ammunition running low, Oliva suggested that the Brigade 2506 retreat into the Escambray mountains to wage guerilla warfare, but San Román decided to hold the beachhead.