Kenin opened the 2020 seasons by playing the Premier-level events at Brisbane and Adelaide, falling in the second round of both tournaments to Osaka and compatriot Danielle Collins respectively. She also played doubles with Mattek-Sands in Adelaide, but the pair fell in the semifinals to the eventual champions Nicole Melichar and Xu Yifan. Seeded 14th at the Australian Open, Kenin recorded straight-set wins over qualifiers Martina Trevisan and compatriot Ann Li to reach the third round for the first time. She then overcame a double break deficit in the first set to defeat 2016 quarterfinalist Zhang Shuai and advance to the fourth round, where she defeated Coco Gauff to reach the quarterfinals. Kenin went on to defeat Ons Jabeur in straight sets, advancing to her first semifinal at a Grand Slam championship. She then defeated the top seed Ashleigh Barty in straight sets to reach the final, where she defeated Garbiñe Muguruza in three sets to claim the trophy. Eventually, she entered the Top ten worldwide by ranking 7th on Feb 3, 2020.