What happened 627 AD

A large epidemic of plague breaks out in Ctesiphon, the capital of the Sasanian Empire, killing more than 100,000 people.

The main Sassanid force was destroyed at Nineveh in 627.

The Assyrian Empire was severely crippled following the death of Ashurbanipal in 627 BC, the nation and its empire descending into a prolonged and brutal series of civil wars involving three rival kings, Ashur-etil-ilani, Sin-shumu-lishir and Sin-shar-ishkun. Egypt's 26th Dynasty, which had been installed by the Assyrians as vassals, quietly detached itself from Assyria, although it was careful to retain friendly relations.