On 9 November 2020, Pfizer released their trial results for a candidate vaccine, showing that it is 90% effective against the virus. Later that day, Novavax entered an FDA Fast Track application for their vaccine. The 9 November announcement does not mean the vaccine is about to be released. However, virologist and U.S. National Institute of Allergy and Infectious Diseases director Dr. Anthony Fauci indicated that the Pfizer vaccine targets the spike protein used to infect cells by the virus. Some issues left to be answered are how long the vaccine offers protection, and if it offers the same level of protection to all ages. Initial doses will likely go to healthcare workers on the front lines.
On November 11, 2020, Biden chose Ron Klain as his White House Chief of Staff. Klain was a Senate aide to Biden in the 1980s, Biden's first chief of staff as Vice President, and chief of staff to Vice President Al Gore.
Trump's allegations of widespread voting fraud were refuted by judges, state election officials, and his own administration's Cybersecurity and Infrastructure Security Agency (CISA). After CISA director Chris Krebs contradicted Trump's voting fraud allegations, Trump fired him on November 17.
On November 23, 2020, Biden made his first national security nominations and appointments, nominating Antony Blinken for Secretary of State, Alejandro Mayorkas for Secretary of Homeland Security, Avril Haines for Director of National Intelligence, Jake Sullivan for National Security Advisor, Linda Thomas-Greenfield for United States Ambassador to the United Nations, and former Secretary of State John Kerry for Special Presidential Envoy for Climate.
Also on November 23, General Services Administrator Emily W. Murphy formally recognized Biden as the apparent winner of the 2020 election and authorized the start of a transition process to the Biden administration.
On 26 November, Maradona's wake, which was attended by tens of thousands of people, was cut short by his family as his coffin was relocated from the rotunda of the Presidential Palace after fans took over an inner courtyard and also clashed with police.
In November 2020, Bezos announced $791M of donations to established, well-known groups, with $100M each going to Environmental Defense Fund, Natural Resources Defense Council, The Nature Conservancy, World Resources Institute, and World Wildlife Fund, and the remainder going to 11 other groups.
At the start of 2020, Musk was the 35th richest person in the world. Throughout that year, his net worth increased by $150 billion, largely driven by his ownership of around 20% of Tesla stock. During this, Musk's net worth was often volatile. For example, it dropped $16.3 billion in September, the largest such plunge according to Bloomberg. In November of that year, Musk passed Facebook co-founder Mark Zuckerberg to become the third-richest person in the world; a week later he passed Microsoft co-founder Bill Gates to become the second-richest.