New England, North Dakota, U.S.
Hernandez made his professional regular-season debut and the first career start in the Patriots' season-opener against the Bengals and recorded one reception for 45-yards during their 38–24 victory. On September 19, 2010, he caught a season-high six receptions for a total of 101 receiving yards during the Patriots' 28–14 loss at the New York Jets in Week 2. Hernandez became the youngest player since 1960 to have more than 100 receiving yards in a single game. In Week 3, Hernandez led all Patriots receivers with six catches for 65-yards during a 38–30 win against the Buffalo Bills. He also had his first career carry for a three-yard gain against the Bills in Week 3. On November 7, 2010, Hernandez caught five passes for 48-yards and scored the first two touchdowns of his career during a 34–14 loss at the Cleveland Browns in Week 9. He caught his first career touchdown on a two-yard pass by Patriots' quarterback Tom Brady during the second quarter. His second touchdown of the game was scored on a one-yard pass by Brady in the fourth quarter.