Diego de Castro Titu Cusi Yupanqui (1529 – 1571) was an Inca ruler of Vilcabamba and the penultimate leader of the Neo-Inca State. He was a son of Manco Inca Yupanqui, He was crowned in 1563, after the death of his half-brother, Sayri Tupac. He ruled until his death in 1571, probably of pneumonia.
