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  • Ḷḷuarca, Valdés, Asturias, Spain
    Sunday Sep 24, 1905

    Ochoa's birth

    Ḷḷuarca, Valdés, Asturias, Spain
    Sunday Sep 24, 1905

    Ochoa was born in Luarca (Asturias), Spain. His father was Severo Manuel Ochoa, (who he was named after), a lawyer and businessman,and his mother was Carmen de Albornoz.




  • Malaga, Spain
    1912

    Ocha's father death

    Malaga, Spain
    1912

    His father died when Ochoa was seven, and he and his mother moved to Málaga, where he attended elementary school through high school.




  • Malaga, Spain
    1920s

    Santiago Ramón y Cajal's influence

    Malaga, Spain
    1920s

    Ochoa's interest in biology was stimulated by the publications of the Spanish neurologist and Nobel laureate Santiago Ramón y Cajal.




  • Madrid, Spain
    1923

    Joining University of Madrid

    Madrid, Spain
    1923

    In 1923, he went to the University of Madrid Medical School, where he hoped to work with Cajal, but Cajal retired. He studied with father Pedro Arrupe, and Juan Negrín was his teacher.




  • Madrid, Spain
    1930s

    Isolating creatinine

    Madrid, Spain
    1930s

    Negrín encouraged Ochoa and another student, José Valdecasas, to isolate creatinine from urine. The two students succeeded and also developed a method to measure small levels of muscle creatinine.




  • Glasgow, Scotland, United Kingdom
    1927

    Summer in Glasgow

    Glasgow, Scotland, United Kingdom
    1927

    Ochoa spent the summer of 1927 in Glasgow working with D. Noel Paton on creatine metabolism improving his English skills.




  • Madrid, Spain
    1927

    Biochemistry career beginning

    Madrid, Spain
    1927

    During the summer he refined the assay procedure further and upon returning to Spain he and Valdecasas submitted a paper describing the work to the Journal of Biological Chemistry, where it was rapidly accepted, marking the beginning of Ochoa's biochemistry career.


  • Dahlem, Berlin, Germany
    1929

    Otto Meyerhof's laboratory

    Dahlem, Berlin, Germany
    1929

    Ochoa completed his undergraduate medical degree in the summer of 1929 and developed an interest in going abroad to gain further research experience. His previous creatine and creatinine work led to an invitation to join Otto Meyerhof's laboratory at the Kaiser Wilhelm Institute for Biology in Berlin-Dahlem in 1929.


  • Madrid, Spain
    1930

    MD thesis research

    Madrid, Spain
    1930

    In 1930 Ochoa returned to Madrid to complete research for his MD thesis, which he defended that year, and minted a new MD in 1931.


  • Madrid, Spain
    1932

    Getting married

    Madrid, Spain
    1932

    Ochoa married Carmen García Cobián, he did not have any children.


  • London, England, United Kingdom
    1932

    Postdoctoral study at the London

    London, England, United Kingdom
    1932

    He then began postdoctoral study at the London National Institute for Medical Research (NIMR), where he worked with Henry Hallett Dale. His London research involved the enzyme glyoxalase and was an important departure in Ochoa's career in two respects. First, the work marked the beginning of Ochoa's lifelong interest in enzymes. Second, the project was at the cutting edge of the rapidly evolving study of intermediary metabolism.


  • Madrid, Spain
    1933

    Returning to Madrid

    Madrid, Spain
    1933

    In 1933 the Ochoas returned to Madrid where he began to study glycolysis in heart muscle.


  • Madrid, Spain
    1935

    Spanish Civil War

    Madrid, Spain
    1935

    Within two years, he was offered the directorship of the Physiology Section in a newly created Institute for Medical Research at the University of Madrid Medical School. Unfortunately the appointment was made just as the Spanish Civil War erupted. Ochoa decided that trying to perform research in such an environment would destroy forever his "chances of becoming a scientist." Thus, "after much thought, my wife and I decided to leave Spain."


  • Germany, England and U.S.
    Sep, 1936

    Wander years

    Germany, England and U.S.
    Sep, 1936

    In September 1936 Severo and Carmen began what he later called the "wander years" as they traveled from Spain to Germany, to England, and ultimately to the United States within a span of four years.


  • Germany
    1936

    Leading world's foremost biochemical facilities

    Germany
    1936

    Ochoa left Spain and returned to Meyerhof's Kaiser Wilhelm Institute for Biology now relocated in Heidelberg, where Ochoa found a profoundly changed research focus. By 1936 Meyerhof's laboratory had become one of the world's foremost biochemical facilities focused on processes such as glycolysis and fermentation. Rather than studying muscles "twitch," the lab was now purifying and characterizing the enzymes involved in muscle action but were involved in yeast fermentation.


  • Oxford, Oxfordshire, England, United Kingdom
    1938

    Ochoa in Oxford

    Oxford, Oxfordshire, England, United Kingdom
    1938

    From 1938 until 1941 he was Demonstrator and Nuffield Research Assistant Ocho at the University of Oxford.


  • Euclid Ave, St. Louis, Missouri, U.S.
    1940

    Washington University

    Euclid Ave, St. Louis, Missouri, U.S.
    1940

    Ochoa then went to the United States, where he again held many positions at several universities. Between 1940 and 1942, Ochoa worked for the Faculty of Medicine of Washington University in St. Louis.


  • 560 1st Ave, New York, U.S.
    1942

    New York University School of Medicine

    560 1st Ave, New York, U.S.
    1942

    In 1942 he was appointed Research Associate in Medicine at the New York University School of Medicine and there subsequently became Assistant Professor of Biochemistry (1945), Professor of Pharmacology (1946), Professor of Biochemistry (1954), and Chairman of the Department of Biochemistry.


  • Stockholm, Sweden
    1959

    Receiving a Nobel Prize

    Stockholm, Sweden
    1959

    In 1959, Ochoa and Arthur Kornberg were awarded the Nobel Prize for Physiology or Medicine "for their discovery of the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic acid".


  • U.S.
    1978

    U.S. National Medal of Science

    U.S.
    1978

    Ochoa received the U.S. National Medal of Science in 1978.


  • Madrid, Spain
    1985

    Spanish science policy authorities

    Madrid, Spain
    1985

    Ochoa continued research on protein synthesis and replication of RNA viruses until 1985, when he returned to Spain and gave advice to Spanish science policy authorities.


  • Madrid, Spain
    Monday Nov 01, 1993

    Ochowa's death

    Madrid, Spain
    Monday Nov 01, 1993

    Severo Ochoa died in Madrid, Spain on 1 November 1993.


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