At the 2017 US Open, Kenin advanced beyond the first round of a Grand Slam tournament for the first time, defeating compatriots Lauren Davis and Sachia Vickery before losing to the 2006 champion Maria Sharapova in the third round. These were also her first two match wins on the WTA Tour. Kenin's success at the US Open helped convince her to turn professional in September, foregoing a scholarship to attend the University of Miami. She finished the year ranked No. 108 in the world.