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In 1526 Spanish Conquistador Francisco de Montejo successfully petitioned the King of Spain for a charter to conquer Yucatán. His first campaign in 1527, which covered much of the Yucatán Peninsula, decimated his forces but ended with the establishment of a small fort at Xaman Haʼ, south of what is today Cancún.

The empire's push into the Amazon Basin near the Chinchipe River was stopped by the Shuar in 1527. The empire extended into the corners of Argentina and Colombia. However, most of the southern portion of the Inca empire, the portion denominated as Qullasuyu, was located in the Altiplano.

Huáscar Inca was Sapa Inca of the Inca Empire from 1527 to 1532. He succeeded his father, Huayna Capac, and his brother Ninan Cuyochi, both of whom died of smallpox while campaigning near Quito.

In Basle, Paracelsus burns standard medical textbooks as a protest against the current teaching and practice of medicine.

The Renaissance ended with the sack of Rome by Spanish and German Imperial troops.

The ninth child and sixth daughter of King Edward IV, Catherine of York, died at the age of 48.

The Bishop of Utrecht, Henry of the Palatinate, gave lands to the Habsburgs in exchange for security help against resistant citizens in the Treaty of Schoonhoven.

In 1526 Spanish Conquistador Francisco de Montejo successfully petitioned the King of Spain for a charter to conquer Yucatán. His first campaign in 1527, which covered much of the Yucatán Peninsula, decimated his forces but ended with the establishment of a small fort at Xaman Haʼ, south of what is today Cancún.

The empire's push into the Amazon Basin near the Chinchipe River was stopped by the Shuar in 1527. The empire extended into the corners of Argentina and Colombia. However, most of the southern portion of the Inca empire, the portion denominated as Qullasuyu, was located in the Altiplano.

Huáscar Inca was Sapa Inca of the Inca Empire from 1527 to 1532. He succeeded his father, Huayna Capac, and his brother Ninan Cuyochi, both of whom died of smallpox while campaigning near Quito.

In Basle, Paracelsus burns standard medical textbooks as a protest against the current teaching and practice of medicine.

The Renaissance ended with the sack of Rome by Spanish and German Imperial troops.

The ninth child and sixth daughter of King Edward IV, Catherine of York, died at the age of 48.

The Bishop of Utrecht, Henry of the Palatinate, gave lands to the Habsburgs in exchange for security help against resistant citizens in the Treaty of Schoonhoven.