What happened 1516 AD

In 1516, Ferdinand II of Aragon, grandfather of the future Holy Roman Emperor Charles V, died.

In 1516, Leonardo was invited by King Francis I to work at the Clos Lucé near the Château d'Amboise; it is believed that he took the Mona Lisa with him and continued to work on it after he moved to France.

In 1516, Leonardo entered Francis' service, being given the use of the manor house Clos Lucé, near the king's residence at the royal Château d'Amboise. Being frequently visited by Francis, he drew plans for an immense castle town the king intended to erect at Romorantin, and made a mechanical lion, which during a pageant walked toward the king and—upon being struck by a wand—opened its chest to reveal a cluster of lilies. Leonardo was accompanied during this time by his friend and apprentice, Francesco Melzi, and supported by a pension totalling 10,000 scudi. At some point, Melzi drew a portrait of Leonardo; the only others known from his lifetime were a sketch by an unknown assistant on the back of one of Leonardo's studies (c. 1517) and a drawing by Giovanni Ambrogio Figino depicting an elderly Leonardo with his right arm assuaged by cloth. The latter, in addition to the record of an October 1517 visit by Louis d'Aragon, confirms an account of Leonardo's right hand being paralytic at the age of 65, which may indicate why he left works such as the Mona Lisa unfinished. He continued to work at some capacity until eventually becoming ill and bedridden for several months.

On 24 August 1516, at the Battle of Marj Dabiq, al-Ghawri was killed. Syria passed into Ottoman possession, and the Ottomans were welcomed in many places as deliverance from the Mamluks.

Al-Ashraf Abu Al-Nasr Tuman bay, better known as Tuman bay II, was the last Sultan of Egypt before the country's conquest by the Ottoman Turks in 1517.

Georg Fabricius was born in Chemnitz, Germany.

"The German Beer Purity Law" (Reinheitsgebot) was endorsed by Duke Wilhelm IV of Bavaria, who added it to the standards for the sale of beer in the state.