Charles V (24 February 1500 – 21 September 1558) was Holy Roman Emperor and Archduke of Austria from 1519, King of Spain (Castile and Aragon) from 1516, and Lord of the Netherlands as titular Duke of Burgundy from 1506. As head of the rising House of Habsburg during the first half of the 16th century, his dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with direct rule over the Austrian hereditary lands and the Burgundian Low Countries, and a unified Spain with its southern Italian kingdoms of Naples, Sicily, and Sardinia. Furthermore, his reign encompassed both the long-lasting Spanish and short-lived German colonizations of the Americas. The personal union of the European and American territories of Charles V was the first collection of realms labelled "the empire on which the sun never sets".