On 17 September 1570, the Ottoman cavalry appeared before the last Venetian stronghold in Cyprus, Famagusta. The Venetian defenders would hold out for 11 months against a force that would come to number 200,000 men with 145 cannons; 163,000 cannonballs struck the walls of Famagusta before it fell to the Ottomans in August 1571. The Siege of Famagusta claimed 50,000 Ottoman casualties.
Túpac Amaru was the last legitimate Inca to rule (in the Vilcabamba region as the Neo-Inca State). With the death of his elder brother Titu Cosi, he ordered the execution of all Spanish people living in Vilcabamba and led an unsuccessful and poorly planned rebellion against the colonists. This resulted in his death and the end of Incan sovereignty, for Vilcabamba was occupied and the survivors enslaved.
Meanwhile, the Holy league consisting of mostly Spanish and Venetian fleets won a victory over the Ottoman fleet at the Battle of Lepanto (1571), off southwestern Greece; Catholic forces killed over 30,000 Turks and destroyed 200 of their ships.