By 1624, Galileo had used a compound microscope. He gave one of these instruments to Cardinal Zollern in May of that year for presentation to the Duke of Bavaria, and in September, he sent another to Prince Cesi.
Possibly the first house erected within the site was that of a Sir William Blake, around 1624. The next owner was Lord Goring, who from 1633 extended Blake's house and developed much of today's garden, then known as Goring Great Garden.