What happened 250 AD

Plague of Cyprian breaks out in Rome. It is estimated to kill about 5000 people a day.

The Maya reached the height of their civilization during the Classic Period of Maya civilization (A.D 250 to 900).

Early Classic era from AD 250 to 550.

Diodotus, the satrap of Bactria founded the Greco-Bactrian Kingdom when he seceded from the Seleucid Empire around 250 BC and became King Diodotus I of Bactria.

During the Early Classic, cities throughout the Maya region were influenced by the great metropolis of Teotihuacan in the distant Valley of Mexico.

After Zenodotus either died or retired, Ptolemy II Philadelphus appointed Apollonius of Rhodes (lived c. 295–c. 215 BC), a native of Alexandria and a student of Callimachus, as the second head librarian of the Library of Alexandria. Philadelphus also appointed Apollonius of Rhodes as the tutor to his son, the future Ptolemy III Euergetes.