Hernandez's father died in January 2006, from complications from hernia surgery, when Hernandez was 16. According to his mother, Hernandez was greatly affected by his father's death, and he acted out his grief by rebelling against authority figures. Those who knew him said he never got over his father's death. Hernandez became estranged from his mother and largely moved in with Tanya Singleton, his older cousin. Following Dennis's death, the family learned that Terri Hernandez and Singleton's husband, Jeff Cummings, had been having an extramarital affair. After the affair became public, Singleton and Cummings divorced, and Cummings moved in with Terri. This "enraged" Hernandez. It was while he was living with Singleton that Hernandez became more involved in criminal activity.
The Reebok takeover was completed with partnership in January 2006 and meant that the company would have business sales closer to those of Nike in North America. The acquisition of Reebok would also allow Adidas to compete with Nike worldwide as the number two athletic shoemaker in the world.
In January 2006 IHA (Ithaca Health Alliance) launched the Ithaca Free Clinic, bringing to life key aspects of Adams's vision. Adams has also given strong praise to Health Democracy, Glover's book written and published the same year.
On January 13, 2006, the Central Intelligence Agency, aided by Pakistan's ISI, launched an airstrike on Damadola, a Pakistani village near the Afghan border where they believed al-Zawahiri was located. The airstrike was supposed to kill al-Zawahiri and this was reported in international news over the following days. Many victims of the airstrike were buried without being identified. Anonymous U.S. government officials claimed that some terrorists were killed and the Bajaur tribal area government confirmed that at least four terrorists were among the dead.
When the Lakers faced the Heat on January 16, 2006, O'Neal and Bryant made headlines by engaging in handshakes and hugs before the game, an event that was believed to signify the end of the so-called "Bryant–O'Neal feud" that had festered since the center left Los Angeles.
On January 22, 2006, Bryant scored a career-high 81 points in a 122–104 victory against the Toronto Raptors. In addition to breaking the previous franchise record of 71 set by Elgin Baylor, Bryant's 81-point game was the second-highest point total in NBA history, surpassed only by Chamberlain's 100-point game in 1962. Whereas Chamberlain was fed repeatedly by teammates for inside shots in a blowout win, Bryant created his own shot—mostly from the outside—in a game which the Lakers trailed at halftime by 14 and did not pull away until the fourth quarter. Chamberlain, playing in an era when the games were paced faster and scoring opportunities were more plentiful, accounted for 59 percent of his team's points in Philadelphia's 169–147 win, compared to Bryant scoring 66 percent of the Lakers' 122 points.
Anti-American protests broke out around the country and the Pakistani government condemned the U.S. attack and the loss of innocent life. On January 30, a new video was released showing al-Zawahiri unhurt. The video discussed the airstrike, but did not reveal if al-Zawahiri was present in the village at that time.