Zuckerberg was born on May 14, 1984, in White Plains, New York.

On February 4, 2004, Zuckerberg launched "The Facebook", originally located at thefacebook.com.

On May 24, 2007, Zuckerberg announced Facebook Platform, a development platform for programmers to create social applications within Facebook.

On November 6, 2007, Zuckerberg announced Beacon, a social advertising system that enabled people to share information with their Facebook friends based on their browsing activities on other sites.

On May 19, 2010, Facebook's website was temporarily blocked in Pakistan until Facebook removed the contest from its website at the end of May. Sidiqque (Pakistani Deputy Attorney General) also asked its UN representative to raise the issue with the United Nations General Assembly.

On July 21, 2010, Zuckerberg reported that the Facebook reached the 500 million-user mark.

On September 22, 2010, it was reported that Zuckerberg had donated $100 million to Newark Public Schools, the public school system of Newark, New Jersey.

A movie based on Zuckerberg and the founding years of Facebook, The Social Network was released on October 1, 2010, starring Jesse Eisenberg as Zuckerberg.

On December 9, 2010, Zuckerberg, Bill Gates, and investor Warren Buffett signed "The Giving Pledge", in which they promised to donate to charity at least half of their wealth over the course of time, and invited others among the wealthy to donate 50 percent or more of their wealth to charity.

On May 19, 2012, Zuckerberg and Chan married in an event that also celebrated her graduation from medical school.

On October 1, 2012, Zuckerberg visited Russian Prime Minister Dmitry Medvedev in Moscow to stimulate social media innovation in Russia and to boost Facebook's position in the Russian market.

On April 11, 2013, Zuckerberg led the launch of a 501 lobbying group called FWD.us. The founders and contributors to the group were primarily Silicon Valley entrepreneurs and investors, and its president was Joe Green, a close friend of Zuckerberg.

On August 19, 2013, The Washington Post reported that Zuckerberg's Facebook profile was hacked by an unemployed web developer.

On December 19, 2013, Zuckerberg announced a donation of 18 million Facebook shares to the Silicon Valley Community Foundation, to be executed by the end of the month—based on Facebook's valuation as of then, the shares totaled $990 million in value.

Alongside other American technology figures like Jeff Bezos and Tim Cook, Zuckerberg hosted visiting Chinese politician Lu Wei, known as the "Internet czar" for his influence in the enforcement of China's online policy, at Facebook's headquarters on December 8, 2014. The meeting occurred after Zuckerberg participated in a Q&A session at Tsinghua University in Beijing, China, on October 23, 2014, where he attempted to converse in Mandarin Chinese; although Facebook is banned in China, Zuckerberg is highly regarded among the people and was at the university to help fuel the nation's burgeoning entrepreneur sector.

On December 1, 2015, Zuckerberg and Chan announced the birth of their first daughter Max, and in an open letter to Max, they pledged to donate 99% of their Facebook shares, then valued at US$45 billion, to the Chan Zuckerberg Initiative, their new organization that will focus on health and education.

On December 1, 2015, Mark and Chan announced they would eventually give 99 percent of their Facebook shares (worth about US$45 billion at the time) to the Chan Zuckerberg Initiative.

On July 2, 2016, Israeli cabinet minister Gilad Erdan accused Zuckerberg of having some responsibility for deadly attacks by Palestinians against Israelis.

On May 28, 2017, Zuckerberg received an honorary degree from Harvard.

On April 10 and April 11, 2018, Zuckerberg began testifying before the United States Senate Committee on Commerce, Science, and Transportation regarding the usage of personal data by Facebook in relation to the Facebook–Cambridge Analytica data breach.