Siege of Castelnuovo

In 1539, a 60,000-strong Ottoman army besieged the Spanish garrison of Castelnuovo on the Adriatic coast; the successful siege cost the Ottomans 8,000 casualties, but Venice agreed to terms in 1540, surrendering most of its empire in the Aegean and the Morea. France and the Ottoman Empire, united by mutual opposition to Habsburg rule, became strong allies.