Born in the city of Málaga in the Andalusian region of Spain.

Picasso's father and uncle decided to send the young artist to Madrid's Real Academia de Bellas Artes de San Fernando, the country's foremost art school. At age 16, Picasso set off for the first time on his own, but he disliked formal instruction and stopped attending classes soon after enrollment.

Picasso made his first trip to Paris, then the art capital of Europe, in 1900. There, he met his first Parisian friend, journalist and poet Max Jacob, who helped Picasso learn the language and its literature

In 1907, Picasso joined an art gallery that had recently been opened in Paris by Daniel-Henry Kahnweiler.

In 1911, Picasso was arrested and questioned about the theft of the Mona Lisa from the Louvre. Suspicion for the crime had initially fallen upon Apollinaire due to his links to Géry Pieret, an artist with a history of thefts from the gallery. Apollinaire in turn implicated his close friend Picasso, who had also purchased stolen artworks from the artist in the past. Afraid of a conviction that could result in his deportation to Spain, Picasso denied having ever met Apollinaire. Both were later cleared of any involvement in the painting's disappearance.

In the summer of 1918, Picasso married Olga Khokhlova, a ballerina with Sergei Diaghilev's troupe

Jacqueline Roque (1927–1986) worked at the Madoura Pottery in Vallauris on the French Riviera, where Picasso made and painted ceramics. She became his lover, and then his second wife in 1961. The two were together for the remainder of Picasso's life.

Pablo Picasso died on 8 April 1973 in Mougins, France from pulmonary edema and heart failure.